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A practical handbook on the pharmacovigilance of antimalarial medicines |
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Категория: Медицина, здравоохранение » Прочая медицинская литература |
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Автор: World Health Organization
Издательство: World Health Organization
Год издания: 2008
isbn: 9241547499
Количество страниц: 175
Язык: english
Формат: PDF
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The IPCS Harmonization Project goal is to improve chemical risk assessment globally, through the pursuit of common principles and approaches, and, hence, strengthen national and international management practices that deliver better protection of human health and the environment within the framework of sustainability. The Harmonization Project aims to harmonize global approaches to chemical risk assessment, including by developing international guidance documents on specific issues. The guidance is intended for adoption and use in countries and by international bodies in the performance of chemical risk assessments. The guidance is developed by engaging experts worldwide. The project has been implemented using a step-wise approach, first sharing information and increasing understanding of methods and practices used by various countries, identifying areas where convergence of different approaches would be beneficial and then developing guidance that enables implementation of harmonized approaches. The project uses a building block approach, focusing at any one time on the aspects of risk assessment that are particularly important for harmonization. |
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Рассказы о русских кораблестроителях |
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Категория: Технические науки » Транспорт » Водный транспорт, судостроение |
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Автор: Быховский И.А.
Издательство: Судостроение
Год издания: 1966
Количество страниц: 286
Язык: русский
Формат: DJVU
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Книга содержит очерки о жизни, деятельности и творческом наследии талантливых русских кораблестроителей прошлых столетий и изобретателей-конструкторов первых отечественных подводных лодок.
Все очерки, созданные на документальном материале, рассчитаны на широкий круг читателей, интересующихся историей отечественного кораблестроения.
Книга иллюстрирована многими публикуемыми впервые фотографиями, а также снабжена справочными данными. |
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Год 1941. Юго-Западный фронт |
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Категория: Отечественная история, История войн |
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Автор: Коллектив
Издательство: Каменяр
Год издания: 1975
Количество страниц: 354
Язык: русский
Формат: DJVU
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Воспоминания, очерки, документы.
Это книга о тех, кто принял и стойко отражал первые удары немецко-фашистских захватчиков на Юго-Западном фронте в грозном сорок первом году. В воспоминаниях участников боев, в очерках журналистов, писателей, в документах рассказывается о бойцах, командирах и политработниках Красной армии, которые в неравных схватках с численно превосходящими силами гитлеровских полчищ проявили исключительное мужество, упорство, беспримерный героизм, самоотверженно защищая каждую пядь родной Советской земли, закладывая фундамент победы над злейшим врагом человечества - германским фашизмом. Сборник охватывает события от приграничных сражений до начала оборонительных боев на ближних подступах к Киеву.
2-е издание, дополненное. |
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Твой малыш (2010 No.11) |
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Категория: Домоводство, досуг » Женские журналы |
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Издательство: Эдипресс-Конлига
Год издания: 2010
Количество страниц: 94
Язык: русский
Формат: PDF (scan)
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Твой Малыш - журнал для современных родителей. Вы – современные родители и хотите быть в курсе новых методик воспитания, оригинальных подходов к решению проблем и последних достижений педиатрии? Тогда наш журнал – для вас! |
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Cities of Dispersal (Architectural Design) |
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Категория: Технические науки » Архитектура и строительство |
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Автор: Rafi Segal, Els Verbakel
Издательство: Wiley
Год издания: 2008
isbn: 0470066377
Количество страниц: 139
Язык: english
Формат: PDF (scan)
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Questioning the traditional boundaries between cities, suburbs, countryside and wilderness, this issue of AD explores emergent types of public space in low-density environments. It describes this new form of urbanism: decentralised, in a constant process of expansion and contraction, not homogenous or necessarily low-rise, nor guided by one mode of development, typology or pattern.
While functionally and programmatically dispersed, settlements operate as a form of urbanism; the place of collective spaces within them has yet to be defined and articulated. The physical transformation of the built environment on the one hand, and the change in our notion of the public on the other - due to globalisation, privatisation and segregation - call for renewed interpretations of the nature and character of public space. The concept of public space needs to be examined: replaced, re-created or adapted to fit these conditions. What is the place of the public in this form of urbanism, and how can architecture address the notion of common, collective spaces? What is the current sociopolitical role o such spaces? How does the form and use of these spaces reflect the conception of the public as a political (or non-political) body? And can architecture regain an active role in formulating the notion of the collective? These and other issues are addressed through essays, research projects and built work by distinguished writers such as Bruce Robbins, Albert Pope and Alex Wall, and Practitioners including Zvi Hecker, Vito Acconci, MUTOPIA, Manuel de Sola-Morales, Martha Rosler and Manuel Vicente in a search for new collective architectures within the dispersed city. |
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Cyclooxygenases: Methods and Protocols |
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Категория: Естественные науки » Химические науки |
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Автор: Samir S.Ayoub, Roderick J.Flower, Michael P.Seed
Издательство: Humana Press
Год издания: 2010
isbn: 1588299538
Количество страниц: 218
Язык: english
Формат: PDF
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The nonsteroidal anti-inflammatory drugs (NSAIDs) consist of more than 40 compounds, which are the most widely used group of medicines worldwide for the treatment of inflammation, pain, fever, and for the prevention of thrombosis. It was through the pivotal work of the late Professor Sir John Vane in the early 1970s that it was realized that the mechanism of pharmacological and toxicological actions of these compounds depended on the inhibition of the catalytic activity of the cyclooxygenase (COX) enzyme resulting in the reduction of prostaglandin synthesis. After the discovery of the second isoform of COX, named COX-2 in the early 1990s, it became clear that the pharmacological actions of NSAIDs were due to the inhibition of COX-2, while the toxicological actions were due to inhibition of COX-1. Thus COX-1 became known as the “house-keeping” isoform involved in prostaglandin synthesis during physiological processes such as regulation of acid release in the stomach, while COX-2 as the inducible isoform involved in pathological processes such as inflammation, pain, fever, and cancer. Eventually, this led to the development of the first. |
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Люди X No.043 |
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Категория: Детский уголок » Комиксы » «Люди Х» |
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Автор: Миллар М.
Издательство: Комикс ЛТД
Год издания: 2004
Количество страниц: 20
Язык: русский
Формат: DJVU
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Президент США по контролем мутантов?! |
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4dsocial: Interactive Design Environments (Architectural Design) |
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Категория: Технические науки » Архитектура и строительство |
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Автор: Lucy Bullivant
Издательство: Wiley
Год издания: 2007
isbn: 0470319119
Количество страниц: 131
Язык: english
Формат: PDF (scan)
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A new breed of public interactive installations is taking root that overturns the traditional approach to artistic experience. Architects, artists and designers are now creating real-time interactive projects at very different scales and in many different guises. Some dominate public squares or transform a building’s façade – others are more intimate, like wearable computing. All, though, share in common the ability to draw in users to become active participants and co-creators of content, so that the audience becomes part of the project.
Investigating further the paradoxes that arise from this new responsive media at a time when communication patterns are in flux, this title features the work of leading designers, such as Electroland, Usman Haque, Shona Kitchen and Ben Hooker, ONL, Realities United Scott Snibbe. While many works critique the narrow public uses of computing to control people and data, others raise questions about public versus private space in urban contexts; all attempt to offer a unique, technologically mediated form of ‘self-learning’ experience, but which are most effective concepts in practice? |
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Biolding a Successful Board-Test Strategy, 2nd edition |
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Категория: Экономика. Бизнес. Управление » Стратегирование. Корпоративное управление |
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Автор: Stephen F.Scheiber
Издательство: Buttrworth Heinemann
Год издания: 2001
isbn: 0750672803
Количество страниц: 350
Язык: english
Формат: PDF
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When I wrote the first edition of Building a Successful Board-Test Strategy, my intent was to avoid (as much as possible) the malady that plagues many books in our industry: like the products they deal with, they become obsolete before release to the public. To accomplish this goal, the book discussed tools, alternatives, and ways to evaluate and select test strategies, rather than dictating what those strategies should be. In many respects, I succeeded. Most of the comments in the original edition are as true today as when they were written. Nevertheless, the industry refuses to stand still. Test has undergone something of a transformation in the past few years. The migration of production capacity away from traditional manufacturers toward contractors continues to accelerate. Today's army of contractors ranges from "garage shops" catering to complex very-low-volume products to multibillion- dollar megaliths handling board volumes in the millions. |
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Ордер на обыск |
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Категория: Домоводство, досуг » Любовь, эротика |
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Издательство: IN-DG
Количество страниц: 15
Язык: русский
Формат: DJVU
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Ордер на обыск - эротический комикс |
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