| |
Биосенсоры: основы и приложения |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Под ред Тернера Э., Карубе У., Уилсона Дж.
Издательство: Мир
Год издания: 1992
isbn: 5-03-001186-2
Количество страниц: 615
Язык: русский
Формат: DJVU
|
Коллективная монография посвящена одному из важнейших достижений биоэлектрохимии — биосенсорам, «ферментным электродам». Рассмотрено также использование в биосенсорах других компонентов биологических систем: антител, клеток, тканей, целых микроорганизмов. Помимо электрических обсуждаются акустические, оптические и другие датчики. С помощью биосенсоров становится реальным непрерывный мониторинг in vivo метаболитов, ферментов, белков и лекарственных препаратов. Книга предназначена для биохимиков, электрохимиков, биологов, медиков. |
|
| |
|
|
| |
Труды по биохимии |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Фридрих Мишер
Издательство: Наука
Год издания: 1985
Количество страниц: 318
Язык: русский
Формат: DJVU
|
Швейцарский ученый Ф. Мишер (1844—1895) — один из основоположников экспериментальной физиологии, гисто- и цитохимии. Имя Ф. Мишера вошло в историю науки благодаря открытию нуклеиновых кислот. Его исследования по нуклеиновым кислотам и работы по физиологии дыхания, которые включены в данное издание, открыли новую эпоху в биологии. Книга снабжена комментарием и очерком жизни и творчества ученого, а также содержит фрагменты научной переписки. |
|
| |
|
|
| |
Excitatory Amino Acids - Clinical Results with Antagonists |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: P.L.Herrling
Издательство: Academic Press
Год издания: 1997
isbn: 0125468202
Количество страниц: 171
Язык: english
Формат: PDF
|
The excitatory effect of glutamate and aspartate on central nervous system neurons described in the early 1960s (Curtis and Watkins, 1960; Krnjevic and Phillis, 1963) initiated a massive research effort aimed at proving these compounds as important neurotransmitters. During the 1980s, glutamate gained the status of the major excitatory neurotransmitter in the brain. Receptors were classified as N-methyl-Daspartate (NMDA) and non-NMDA receptors, based on electrophysiological studies (Hicks et al., 1978; Davies et al., 1979; Watkins and Evans, 1981; McLennan and Liu, 1982). NMDA receptors are stimulated most potently by NMDA itself. Currents activated by NMDA receptors are carried by Na § K § and Ca 2§ (Dingledine, 1983; MacDermott et al., 1986). The non-NMDA receptors were later divided into three groups, t~- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, kainate receptors, and metabotropic glutamate receptors, based on the preferred agonists, AMPA, kainate, and glutamate (for a review, see Watkins et al., 1990). AMPA and kainate receptors are ion channel coupled mainly Na § channels, whereas metabotropic glutamate receptors mediate responses via G-protein-coupled second messengers. |
|
| |
|
|
| |
Erythropoietins, Erythropoietic Factors, and Erythropoiesis Molecular, Cellular, Preclinical, and Clinical Biology, 2nd edition |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Steven G.Elliott, Mary Ann Foote, Graham Molineux
Издательство: Birkhauser Verlag
Год издания: 2009
isbn: 3764386940
Количество страниц: 337
Язык: english
Формат: PDF
|
Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the erythropoietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming available on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified, cloned, and expressed, the path was set for the study of other aspects of EPO biology both within erythropoiesis and other cellular systems. |
|
| |
|
|
| |
Ending and Extending Life |
|
|
Категория: Биологические науки, Биохимия. Биофизика |
|
| |
| |
| |
|
Издательство: Facts on File
Год издания: 2010
isbn: 0816062056
Количество страниц: 222
Язык: english
Формат: PDF
|
Ending and Extending Life takes a detailed look at several bold medical innovations that have saved and improved the lives of millions of patients. Mechanical ventilation, organ transplantation and other life-saving surgical techniques, new diagnostic technologies (such as CT and MRI scans), advanced chemotherapy and antiviral drugs, and tube feeding are only a few of the many medical enhancements that have had exciting and complex implications for patients, loved ones, and health care practitioners.
Medical innovation, of course, requires research, and research depends on patients and healthy volunteers willing to assume risks. This new book considers the ethical decisions that medical researchers have to face on the path to discovery, using real patients' stories to highlight key ethical principles and their application to the everyday practice of medicine.
|
|
| |
|
|
| |
Aging of the Genome: The Dual Role of DNA in Life and Death |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Jan Vijg
Издательство: Oxford University Press
Год издания: 2007
isbn: 019856922X
Количество страниц: 384
Язык: english
Формат: PDF
|
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change. |
|
| |
|
|
| |
Nitric Oxide, Second Edition: Biology and Pathobiology |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Louis J. Ignarro
Издательство: Academic Press
isbn: 0123738660
Количество страниц: 250
Язык: english
|
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. |
|
| |
|
|
| |
Bioinorganic Vanadium Chemistry |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Dieter Rehder
Издательство: Wiley
Год издания: 2008
isbn: 0470065095
Количество страниц: 224
Язык: english
Формат: PDF
|
Vanadium is named after Vanadis, the most aristocratic of Norse goddesses, who symbolises beauty and fertility - essential features of vanadium chemistry. It is a ubiquitous trace element, with a surprising range of biological functions. In Bioinorganic Vanadium Chemistry, Dieter Rehder addresses the major aspects of vanadium chemistry related to living organisms and the mutual impact between biological and inorganic vanadium chemistry. |
|
| |
|
|
| |
Endotoxins: Structure, Function and Recognition (Subcellular Biochemistry) |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Xiaoyuan Wang, Peter J. Quinn
Издательство: Springer
Год издания: 2010
isbn: 9048190770
Количество страниц: 450
Язык: english
Формат: PDF
|
Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells |
|
| |
|
|
| |
Nucleic Acid Switches and Sensors (Molecular Biology Intelligence Unit (Unnumbered).) |
|
|
Категория: Биологические науки » Биохимия. Биофизика |
|
| |
| |
| |
|
Автор: Scott K. Silverman
Издательство: Springer
Год издания: 2006
isbn: 0387374914
Количество страниц: 125
Язык: english
Формат: PDF
|
In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
|
|
| |
|
|
|
ПОСТУПЛЕНИЯ
РУБРИКАТОР
Подробнее и с комментариями (0)